Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells
Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation.The Spi1/PU.1 cowboys ps5 controller transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem cells.The deregulation of its expression or activity contributes to leukemia,